Best Supplements for PCOS: Inositol, Berberine and More
Inositol has the most research for PCOS and was reviewed in the 2023 international guideline. Berberine, vitamin D and omega-3s have weaker evidence. See doses.
By the editorial team · Updated Oct 14, 2026 · 2 sources cited
The best supplements for PCOS start with inositol (usually myo-inositol), which may improve some metabolic and hormonal measures, though the 2023 international guideline judged the evidence limited. Berberine, vitamin D and omega-3s have smaller studies. Lifestyle changes and medicines such as metformin or hormonal treatment remain the core of care.
Evidence-ranked options
| Supplement | Evidence | Typical dose | Notes |
|---|---|---|---|
| Myo-inositol | C | 2–4 g a day | May help ovulation and insulin resistance; well tolerated. |
| Berberine | C | 500 mg 2–3 times a day | Small trials; not in pregnancy. |
| Vitamin D (if low) | C | 600–2,000 IU a day | Deficiency is common in PCOS. |
| Omega-3 | C | 1–2 g a day | May lower triglycerides. |
A: strong · B: moderate · C: limited or mixed · D: good evidence of no benefit. See the evidence database.
Lifestyle first
Even a 5% weight loss can improve cycles and insulin sensitivity in PCOS. Regular activity and a diet focused on fiber and protein help. Related: fertility supplements and blood sugar.
Ingredient guides
Frequently asked questions
Is inositol better than metformin for PCOS?
Evidence comparing them is limited. Metformin has more research; some people use both under medical guidance.
Can supplements cure PCOS?
No. PCOS is a long-term condition managed with lifestyle and medical treatment.
Sources
Educational content, not medical advice. Read our medical disclaimer.