Inositol Supplements: Benefits, Dosage and Safety

Summary

Inositol supplements, mainly myo-inositol, are widely used for polycystic ovary syndrome. Some trials show improvements in insulin resistance and ovulation, but a review for the 2023 international PCOS guideline judged the evidence limited. Inositol is generally well tolerated.

Evidence at a glance

UseGradeWhat the research shows
PCOS metabolic and ovulation measuresCSome benefits; evidence judged limited in the 2023 guideline review.

A: strong, consistent human evidence ยท B: moderate ยท C: limited or mixed ยท D: good evidence of no benefit.

Inositol is involved in insulin signaling and is found in fruits, beans and grains.

How to take it

Studies commonly used 2โ€“4 g of myo-inositol daily. See PCOS supplements.

Safety and interactions

High doses can cause nausea or gas. Discuss with your clinician if trying to conceive.

Always tell your doctor and pharmacist about the supplements you take. Check combinations with our interaction checker.

Sources

  1. Fitz V et al. Inositol for polycystic ovary syndrome: systematic review and meta-analysis to inform the 2023 international PCOS guidelines. J Clin Endocrinol Metab. 2024

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